I am subscribed to over 180 feeds and I keep up with most of my professional news through both the Windows and iPhone versions that nicely sync with each other so that an item marked as read on my iPhone syncs with Windows.
Its no exaggeration to say that Google Reader
If you are in the same boat as me and have not found an alternative yet - then take a look at Feedly. It seems they have acquired more than 500,000 Google Reader users in recent days.
Seems Hitler did not take it too well either :-)